|Your version of Ghost has a lot to do with how it works.|
If you have the option in the program then IMO that is the best imaging method.
That said, you must be sure that Ghost recognizes your burner drive by model or you can't span the image over multiple disks.
Also, many versions and/or builds of Ghost don't work with SATA drives. I have Ghost 2003 with the latest updates and it does work with SATA drives.
If using an External USB burner you need to verify that your computer can boot from that device.