|OP doesn't say where the error code comes from, but I'm going to assume it's from Device Manager. In which case, for reference, "Currently, this hardware device is not connected to the computer. (Code 45)"|
With that out of the way, the drive is dead. If this is a removable DVD drive, you can try cleaning the contacts in both the laptop drive bay and on the DVD drive itself, but chances are the drive is dead.
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