|" What might the problem be?"|
Games are well known to have more bugs in them than most other programs, and it's well known they do NOT work properly on all possible computers that at least meet the games minimum requirements. If this happens ONLY with the game, it's probably bugs in the game that's the cause. You could try looking on the game's web site for updates or mentions in FAQs of what you need to do to fix your problem, but often there is no fix and you just cannot use that game.
If you get the error regardless of whether you were playing the game, see this: