|Not enough information.|
Was the game just installed?
Has it worked on this machine before?
Did anything happen recently that might be related (software, hardware, errors, crashes, etc)
What is the make and model of the computer?
What is your graphics (what card or what onboard video)?
Have you had trouble with any other programs recently?
What do you see and hear when you start it?
You have to be a little bit crazy to keep you from going insane.